They Decode The Most Complete Genetic Map of Lupus


An international team of scientists (with the participation of the University of Granada) has deciphered the most complete genetic map to date of systemic lupus erythematosus (SLE), an autoimmune and chronic disease that affects especially women of reproductive age and for which there is no cure . The finding has been published in the journal Nature Genetics  ;.

The researchers performed a genotyping of 4,500 patients identified as having lupus  (LES) and 1,200 healthy adults as a get a handle on group, along with the usage of data from healthy dbGaP controls , a worldwide database of genotypes  and phenotypes orchestrated by the National Center of biotechnology information, a division of the US National Institute of Health.


Up to now, over 50 genes linked to SLE have now been identified. Now, thanks to the new research, 12 new genes related to the pathology have now been discovered . “We also discovered that among those genes  there’s an enrichment of transcription factors, genes that regulate the expression of other genes. At once, they show the cell types where these genes are carrying out their effects, “Marta Alarcón Riquelme, co-author of the research, told the SINC agency.


The analysis (which aims to review patients with various diseases such as for example systemic lupus erythematosus, systemic sclerosis, syndrome  of Sjögren or antiphospholipid syndrome) presents not merely the absolute most complete genetic map of lupus up to now, but a meta-analysis of two cohorts within the illness. This finding allows to classify patients according for their genetic profile and the variants of risk they’ve.